THE SCIENCE BEHIND CHEERS®

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DHMMILK THISTLEPRIckly pearnacvitamins b, c, & eelectrolytes
THE REAL MVP

Dihydromyricetin (DHM)

Dihydromyricetin (DHM) is the main ingredient in Thrive+® After-Alcohol Aid™. DHM is the active ingredient of the Holvenia Dulcis plant. Though the plant was used a traditional hangover tea in Asian countries for over a millennia, only recently was its active ingredient isolated and introduced to the modern world.

Dihydromyricetin has been shown to reduce alcohol’s negative effects through multiple routes, these are: 1) preventing short-term alcohol withdrawal, 2) increasing alcohol and acetaldehyde metabolism, and 3) protecting against alcohol-induced liver damage. These routes with their corresponding studies are listed below:

Preventing short-term alcohol withdrawal: A main cause of hangovers is short-term alcohol withdrawal. When alcohol, a depressant, leaves the system following the consumption of alcohol, individuals go into a state of hyper-excitability caused by alcohol withdrawal. This hyper-excitability, or withdrawal, causes the inability to enter restful sleep, general discomfort, sensitivity to light and sound, the inability to focus, and general lethargy. DHM ameliorates short-term alcohol/hyper-excitability. (1)

Increases acetaldehyde metabolism in liver: The human body cannot directly clear alcohol. It must first break alcohol into acetaldehyde, which is 20 times more toxic than alcohol itself, and then clear this acetaldehyde from the system. Because of the toxic nature of acetaldehyde, the amount and length of acetaldehyde exposure can add to severity of a hangover. DHM enhances the ability to eliminate acetaldehyde via enhancement of acetaldehyde dehydrogenase (ALDH). (2) (3)

Protective effect against alcohol-induced liver damage: Alcohol has adverse effects on the liver due to it having to process large amounts of toxins. Over six weeks, groups given Holvenia Dulcis showed significantly less liver damage when injected with alcohol than groups not receiving Holvenia Dulcis Extract. The Holvenia Dulcis plant has a protective effect against alcohol-induced liver damage. (4)

Studies

Kim, K. H., et al. “Hepatic detoxification activity and reduction of serum alcohol concentration of Hovenia dulcis Thunb from Korea and China.” Korean J Med Crop Sci 8 (2000): 225-233.Chen, S. H., et al. “[Influence of Hovenia dulcis on alcohol concentration in blood and activity of alcohol dehydrogenase (ADH) of animals after drinking].” Zhongguo Zhong yao za zhi= Zhongguo zhongyao zazhi= China journal of Chinese materia medica 31.13 (2006): 1094-1096.Studies: Kim, K. H., et al. “Hepatic detoxification activity and reduction of serum alcohol concentration of Hovenia dulcis Thunb from Korea and China.” Korean J Med Crop Sci 8 (2000): 225-233.Chen, S. H., et al. “[Influence of Hovenia dulcis on alcohol concentration in blood and activity of alcohol dehydrogenase (ADH) of animals after drinking].” Zhongguo Zhong yao za zhi= Zhongguo zhongyao zazhi= China journal of Chinese materia medica 31.13 (2006): 1094-1096.
THE REAL MVP

Dihydromyricetin (DHM)

Dihydromyricetin (DHM) is the main ingredient in Cheers® After-Alcohol Aid™. DHM is the active ingredient of the Holvenia Dulcis plant. Though the plant was used as a traditional hangover tea in Asian countries for over a millennia, only recently was its active ingredient isolated and introduced to the modern world.

Dihydromyricetin has been shown to reduce alcohol’s negative effects through multiple routes, these are: 1) reducing GABAa rebound, 2) increasing alcohol and acetaldehyde metabolism, and 3) protecting against alcohol-induced liver damage. These routes with their corresponding studies are listed below:

Reducing GABAa rebound: A main cause of hangovers is GABAa rebound. When alcohol, a depressant, leaves the system following the consumption of alcohol, individuals go into a state of hyper-excitability caused by GABAa rebound. This hyper-excitability, or rebound, causes the inability to enter restful sleep, general discomfort, sensitivity to light and sound, the inability to focus, and general lethargy. DHM ameliorates short-term alcohol/hyper-excitability. (1)

Increases acetaldehyde metabolism in liver: The human body cannot directly clear alcohol. It must first break alcohol into acetaldehyde, which is 20 times more toxic than alcohol itself, and then clear this acetaldehyde from the system. Because of the toxic nature of acetaldehyde, the amount and length of acetaldehyde exposure can add to severity of a hangover. DHM enhances the ability to eliminate acetaldehyde via enhancement of acetaldehyde dehydrogenase (ALDH). (2) (3)

Protective effect against alcohol-induced liver damage: Alcohol has adverse effects on the liver due to it having to process large amounts of toxins. Over six weeks, groups given Holvenia Dulcis showed significantly less liver damage when injected with alcohol than groups not receiving Holvenia Dulcis Extract. The Holvenia Dulcis plant has a protective effect against alcohol-induced liver damage. (4)

Studies

Kim, K. H., et al. “Hepatic detoxification activity and reduction of serum alcohol concentration of Hovenia dulcis Thunb from Korea and China.” Korean J Med Crop Sci 8 (2000): 225-233.Chen, S. H., et al. “[Influence of Hovenia dulcis on alcohol concentration in blood and activity of alcohol dehydrogenase (ADH) of animals after drinking].” Zhongguo Zhong yao za zhi= Zhongguo zhongyao zazhi= China journal of Chinese materia medica 31.13 (2006): 1094-1096.Studies: Kim, K. H., et al. “Hepatic detoxification activity and reduction of serum alcohol concentration of Hovenia dulcis Thunb from Korea and China.” Korean J Med Crop Sci 8 (2000): 225-233.Chen, S. H., et al. “[Influence of Hovenia dulcis on alcohol concentration in blood and activity of alcohol dehydrogenase (ADH) of animals after drinking].” Zhongguo Zhong yao za zhi= Zhongguo zhongyao zazhi= China journal of Chinese materia medica 31.13 (2006): 1094-1096.
THE ANCIENT REMEDY

Milk Thistle

Milk Thistle (active ingredient Silymarin) has traditionally been used for years as an herbal way to promote liver function and repair. In research, Silymarin opposes alcohol-induced oxidative stress in livers. Preventative use is more effective than curative treatment.

Studies

Lieber, Charles S., et al. “Silymarin retards the progression of alcohol-induced hepatic fibrosis in baboons.” Journal of clinical gastroenterology 37.4 (2003): 336-339.Song, Zhenyuan, et al. “Silymarin Protects Against Acute Ethanol‐Induced Hepatotoxicity in Mice.” Alcoholism: Clinical and Experimental Research 30.3 (2006): 407-413.Das, Subir Kumar, and D. M. Vasudevan. “Protective effects of silymarin, a milk thistle (Silybium marianum) derivative on ethanol-induced oxidative stress in liver.”Indian Journal of Biochemistry and Biophysics 43.5 (2006): 306.Wellington, Keri, and Blair Jarvis. “Silymarin: a review of its clinical properties in the management of hepatic disorders.” BioDrugs 15.7 (2001): 465-489.These studies also reveal that Silymarin supplementation increases glutathione levels in the liver. Glutathione is used in the process to eliminate acetaldehyde. Note: This is only a handful of the available studies. Positive ones are being added to the academic literature every day.
THE FIXER UPPER

Prickly Pear (Opuntia ficus indica)

Prickly Pear (Opuntia ficus indica) is a known anti-oxidant and has been found to diminish an over-reactive inflammatory response to stressful stimuli. In studies, Prickly Pear reduces some of alcohol’s negative effects via inhibiting over-reactive inflammatory response to alcohol.

Studies

Wiese, Jeff, et al. “Effect of Opuntia ficus indica on symptoms of the alcohol hangover.” Archives of Internal Medicine 164.12 (2004): 1334-1340.
Note: This is only a handful of the available studies. Positive ones are being added to the academic literature every day.
THE CLEAN UP CREW

N-Acetyl Cysteine (NAC)

N-Acetyl Cysteine (NAC) is known to be the biological precursor to glutathione and can reduce alcohol-induced oxidative stress and liver toxicity. In studies, NAC has been shown to significantly reduce the liver damage caused by alcohol consumption. This is done by its ability to reduce alcohol-induced stress and liver toxicity.

Studies

Ozaras, Resat, et al. “N-acetylcysteine attenuates alcohol-induced oxidative stess in rats.” World journal of gastroenterology: WJG 9.4 (2003): 791-794.
Jaya, D. S., J. Augustine, and V. P. Menon. “Protective role of N-acetylcysteine against alcohol and paracetamol induced toxicity.” Indian Journal of Clinical Biochemistry 9.2 (1994): 64-71.
Seiva, Fábio Rodrigues Ferreira, et al. “Effects of N-acetylcysteine on alcohol abstinence and alcohol-induced adverse effects in rats.” Alcohol 43.2 (2009): 127-135.
Note: This is only a handful of the available studies. Positive ones are being added to the academic literature every day.
THE FOUNDATION

Vitamins B, C, & E

Vitamins are the building blocks of the human body. Normally, healthy diets and multivitamin supplementation can give individuals all that they need to maintain a healthy lifestyle. However, studies reveal that alcohol intake can reduce absorption of these crucial vitamins. Deficits in vitamins can lead to various health problems such as a lack of energy and weakened immune response. Supplementation of vitamins during or after drinking alcohol can increase total vitamin absorption and negate this alcohol-induced problem. It can also increase physiological and psychological functions surrounding alcohol usage.

Studies

Lecomte, Edith, et al. “Effect of alcohol consumption on blood antioxidant nutrients and oxidative stress indicators.” The American journal of clinical nutrition 60.2 (1994): 255-261.
KELLY, MICHAEL, ANNA‐LISA MYRSTEN, and LEONARD GOLDBERG. “Intravenous vitamins in acute alcoholic intoxication: effects on physiological and psychological functions.” British Journal of Addiction to Alcohol & Other Drugs66.1 (1971): 19-30.
Fairfield, Kathleen M., and Robert H. Fletcher. “Vitamins for chronic disease prevention in adults: scientific review.” Jama 287.23 (2002): 3116-3126.
Swift, Robert, and Dena Davidson. “Alcohol hangover.” Alcohol Health Res World22 (1998): 54-60.
Note: This is only a handful of the available studies. Positive ones are being added to the academic literature every day.
THE HYDRATOR

Electrolytes

Electrolytes are essential to normal human functioning. They are responsible for hydration, muscular contractions, neuronal signaling in the brain, etc. As normally thought of by the general population, dehydration and electrolyte imbalances are in fact some of alcohol’s negative effects and a reason why you don’t feel as good the day following alcohol consumption. Electrolyte intake following the usage of alcohol can aid in restoring electrolyte imbalances.

Studies

Swift, Robert, and Dena Davidson. “Alcohol hangover.” Alcohol Health Res World22 (1998): 54-60.
Note: This is only a handful of the available studies. Positive ones are being added to the academic literature every day.

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